MDD: Caspi et al (2003)
Caspi et al. (2003) conducted a longitudinal correlational study investigating the role of gene–environment interaction (G × E) in depression. Diathesis-stress theories suggest that people may inherit a genetic vulnerability to depression, but stressful life events are needed to trigger the disorder. The study focused on a variation of the serotonin transporter gene (5-HTT), which affects the reuptake of serotonin in...